Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807946 | 1.00 | RAB9A (0.46) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL10727181 | 0.76 | TDP1 (0.55) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL22013648 | 0.75 | TDP1 (0.58) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL8688431 | 0.73 | TDP1 (0.51) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL11701200 | 0.71 | KDM4E (0.38) | KDM4EFDPSALDH1A1GAAENPP2 | |
| Alcohol SCHEMBL10821598 | 0.71 | TDP1 (0.52) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL15667344 | 0.69 | TDP1 (0.57) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL318360 | 0.69 | TDP1 (0.57) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL15667383 | 0.69 | TDP1 (0.57) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL1102248 | 0.68 | CYP3A4 (0.61) | RAB9ANPC1TDP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027680-A1 | 3-(1-CARBAMOYLCYCLOHEXYL) PROPIONIC ACID DERIVATIVES AS INHIBITORS OF NEUTRAL ENDOPEPTIDASE ENZYME | PFIZER LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |