Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807755 | 0.90 | CDK1 (0.60) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3770147 | 0.87 | CDK1 (0.78) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3775610 | 0.85 | CCNB2 (0.65) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3775606 | 0.85 | CCNB2 (0.65) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL5808261 | 0.77 | CCNB2 (0.53) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL13061452 | 0.76 | CDK1 (0.78) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3763115 | 0.76 | CDK1 (1.00) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3769906 | 0.75 | CCNB2 (0.65) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL3769904 | 0.75 | CCNB2 (0.65) | CDK1CCNB2CCNB1CCNB3GSK3B | |
| SCHEMBL13008036 | 0.74 | CDK1 (0.74) | CDK1CCNB2CCNB1CCNB3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050076-A1 | PYRIMIDINYL SUBSTITUTED FUSED-PYRROLYL COMPOUNDS USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |