Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.77 |
| ▸ | SRC | P12931 | 8/20 | 0.77 |
| ▸ | LCK | P06239 | 4/20 | 0.76 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.76 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.76 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.76 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.76 |
| ▸ | EGFR | P00533 | 2/20 | 0.76 |
| ▸ | FYN | P06241 | 2/20 | 0.76 |
| ▸ | CSF1R | P07333 | 2/20 | 0.76 |
| ▸ | YES1 | P07947 | 2/20 | 0.76 |
| ▸ | LYN | P07948 | 2/20 | 0.76 |
| ▸ | RET | P07949 | 2/20 | 0.76 |
| ▸ | HCK | P08631 | 2/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.76 |
| ▸ | BCR | P11274 | 2/20 | 0.76 |
| ▸ | BRAF | P15056 | 2/20 | 0.76 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.76 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.76 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808441 | 1.00 | ABL1 (0.77) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL793188 | 1.00 | ABL1 (0.77) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL17347934 | 0.95 | ABL1 (0.79) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL792953 | 0.92 | ABL1 (0.76) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL16219601 | 0.92 | ABL1 (0.76) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL17367319 | 0.91 | ABL1 (0.78) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL28436547 | 0.91 | ABL1 (0.82) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL5945218 | 0.90 | ABL1 (0.77) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL17348011 | 0.90 | ABL1 (0.82) | ABL1SRCLCKDDR1DDR2 | |
| SCHEMBL17278262 | 0.90 | ABL1 (0.81) | ABL1SRCLCKDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700633-B2 | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof | JENKEM TECHNOLOGY CO., LTD., TIANJIN BRANCH (CN) | 2017-07-11 | — | — | US | disclosed |
| US-20150359900-A1 | CONJUGATES OF WATER SOLUBLE POLYMER-AMINO ACID OLIGOPEPTIDE-DRUG, PREPARATION METHOD AND USE THEREOF | JENKEM TECHNOLOGY CO. LTD., TIANJIN BRANCH (CN) | 2015-12-17 | — | — | US | disclosed |
| WO-2006037032-A2 | PRODRUGS OF PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-06 | — | — | WO | disclosed |
| US-20060069101-A1 | Prodrugs of protein tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069101-A1 | Prodrugs of protein tyrosine kinase inhibitors | ABL1, LCK, BRAF | ABL1 1/4885SRC 4/4885LCK 2/4885 |
| US-20150359900-A1 | CONJUGATES OF WATER SOLUBLE POLYMER-AMINO ACID OLIGOPEPTIDE-DRUG, PREPARATION METHOD AND USE THEREOF | SLC7A1, NPPA, PEPD | ABL1 1982/4885SRC 4644/4885LCK 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.