SCHEMBL580862

SCHEMBL580862

Cc1cc2oc3cc(O)c(O)cc3c2c(=O)o1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.64
MEN1 O00255 5/20 0.64
KMT2A Q03164 5/20 0.64
MAPT P10636 4/20 0.64
CYP3A4 P08684 3/20 0.52
MAPK1 P28482 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
NT5E P21589 1/20 0.52
ANTXR2 P58335 1/20 0.51
HPGD P15428 3/20 0.50
MCL1 Q07820 3/20 0.50
RECQL P46063 3/20 0.50
BLM P54132 3/20 0.50
THRB P10828 2/20 0.50
HSD17B10 Q99714 2/20 0.50
MAOA P21397 2/20 0.50
ALDH1A1 P00352 2/20 0.50
AKR1B1 P15121 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
MMP1 P03956 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10135382 0.90 KDM4E (0.60) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10181612 0.85 KDM4E (0.55) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10181447 0.79 PTGS1 (0.65) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10135387 0.79 KDM4E (0.50) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10181450 0.79 PTGS1 (0.51) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10135385 0.78 MAOA (0.54) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL10182556 0.78 NUAK1 (0.56) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL581188 0.78 KDM4E (0.59) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL580570 0.76 PTGS1 (0.51) KDM4EMEN1KMT2AMAPTCYP3A4
SCHEMBL580976 0.75 KDM4E (0.44) KDM4EMEN1KMT2AMAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP claimed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US claimed
EP-2121141-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2009-11-25 EP claimed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO claimed
EP-2464739-B1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2016-01-13 EP disclosed
US-8859235-B2 Methods in cell cultures, and related inventions, employing certain additives BASF SE (DE) 2014-10-14 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP disclosed
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP disclosed
WO-2011018472-A2 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2011-02-17 WO disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
EP-2121141-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2009-11-25 EP disclosed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO disclosed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS TYR, NQO1, SIRT3 KDM4E 1307/4885MEN1 3538/4885KMT2A 3660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.