Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581015 | 0.95 | MKNK1 (0.43) | AURKAAURKBTPX2KDRCDK4 | |
| SCHEMBL581548 | 0.94 | AURKA (0.40) | AURKAAURKBTPX2KDRCDK4 | |
| SCHEMBL15810117 | 0.92 | AURKA (0.41) | AURKAAURKBTPX2FGFR1KDR | |
| SCHEMBL581894 | 0.91 | AURKB (0.50) | AURKAAURKBTPX2FGFR1KDR | |
| SCHEMBL580464 | 0.87 | AURKA (0.57) | AURKAAURKBTPX2FGFR1KDR | |
| SCHEMBL579093 | 0.86 | AURKB (0.51) | AURKAAURKBTPX2KDRMKNK1 | |
| SCHEMBL580006 | 0.86 | AURKB (0.50) | AURKAAURKBTPX2KDRMKNK1 | |
| SCHEMBL580483 | 0.85 | AURKB (0.49) | AURKAAURKBTPX2ACVR1RET | |
| SCHEMBL581049 | 0.83 | AURKB (0.51) | AURKAAURKBTPX2FGFR1KDR | |
| SCHEMBL581370 | 0.81 | AURKA (0.46) | AURKAAURKBTPX2KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |