Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 4/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580936 | 0.95 | AURKA (0.40) | MKNK1AURKAAURKBTPX2CDK4 | |
| SCHEMBL581548 | 0.94 | AURKA (0.40) | MKNK1AURKAAURKBTPX2CDK4 | |
| SCHEMBL580006 | 0.91 | AURKB (0.50) | MKNK1AURKAAURKBTPX2ACHE | |
| SCHEMBL579093 | 0.91 | AURKB (0.51) | MKNK1AURKAAURKBTPX2ACHE | |
| SCHEMBL15810117 | 0.87 | AURKA (0.41) | MKNK1AURKAAURKBTPX2ACHE | |
| SCHEMBL581894 | 0.86 | AURKB (0.50) | AURKAAURKBTPX2CDK4GSK3B | |
| SCHEMBL581145 | 0.86 | AURKA (0.55) | MKNK1AURKAAURKBTPX2CDK4 | |
| SCHEMBL580483 | 0.85 | AURKB (0.49) | AURKAAURKBTPX2TEKABL1 | |
| SCHEMBL581487 | 0.83 | AURKB (0.51) | MKNK1AURKAAURKBTPX2ACHE | |
| SCHEMBL580836 | 0.82 | AURKB (0.52) | MKNK1AURKAAURKBTPX2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |