Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805764 | 0.85 | HRH3 (0.39) | HRH3KDM1ASLC18A3OPRM1DRD2 | |
| SCHEMBL5806757 | 0.85 | HRH3 (0.41) | HRH3SIGMAR1 | |
| SCHEMBL5805753 | 0.72 | SIGMAR1 (0.39) | HRH3SIGMAR1 | |
| SCHEMBL4564154 | 0.72 | HRH3 (0.43) | HRH3KDM1ASLC18A3OPRM1DRD2 | |
| SCHEMBL5805849 | 0.69 | HRH3 (0.45) | HRH3KDM1ASLC18A3OPRM1DRD2 | |
| SCHEMBL25414060 | 0.67 | TLR9 (0.46) | — | |
| SCHEMBL14012694 | 0.67 | HRH3 (0.47) | HRH3KDM1ASLC18A3OPRM1SIGMAR1 | |
| SCHEMBL14012682 | 0.66 | HRH3 (0.46) | HRH3KDM1ASLC18A3OPRM1SIGMAR1 | |
| SCHEMBL19839243 | 0.66 | TLR9 (0.50) | — | |
| SCHEMBL16255571 | 0.64 | SLC18A3 (0.55) | SLC18A3DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006113458-A1 | HETEROCYCLIC INHIBITORS OF PROTEIN ARGININE METHYL TRANSFERASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-26 | — | — | WO | disclosed |