SCHEMBL5809952

SCHEMBL5809952

Cc1csc2nc(-c3cnccn3)nc(Cl)c12.Cc1csc2nc(-c3cnccn3)nc(NCc3ccc4c(c3)OCO4)c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.42
NPSR1 Q6W5P4 3/20 0.42
ESR1 P03372 1/20 0.42
PDE5A O76074 4/20 0.40
ALDH1A1 P00352 5/20 0.39
MEN1 O00255 5/20 0.39
KMT2A Q03164 5/20 0.39
TSHR P16473 5/20 0.39
TP53 P04637 1/20 0.39
HTT P42858 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
CLK4 Q9HAZ1 5/20 0.38
CLK1 P49759 3/20 0.38
CLK2 P49760 3/20 0.38
DYRK1A Q13627 3/20 0.38
HSD17B10 Q99714 4/20 0.38
CYP1A2 P05177 3/20 0.38
CYP3A4 P08684 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7516589 0.95 ESR1 (0.42) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL5118059 0.95 MAPT (0.45) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL5118413 0.90 ESR1 (0.41) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL7517415 0.87 MAPT (0.58) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL5128338 0.87 BCDIN3D (0.39) MAPTNPSR1PDE5AALDH1A1MEN1
SCHEMBL7509747 0.85 MAPT (0.42) MAPTNPSR1PDE5AALDH1A1MEN1
SCHEMBL5814533 0.85 NPC1 (0.43) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL5119670 0.84 HIF1A (0.46) MAPTNPSR1ESR1PDE5AALDH1A1
SCHEMBL5121202 0.83 MAPT (0.44) MAPTNPSR1PDE5AALDH1A1MEN1
SCHEMBL5122486 0.83 ESR1 (0.48) ESR1CLK4CLK1CLK2DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1685136-A1 USE OF THIENOPYRIMIDINES MERCK PATENT GmbH (DE) 2006-08-02 EP disclosed
WO-2005047292-A1 USE OF THIENOPYRIMIDINES MERCK PATENT GMBH (DE) 2005-05-26 WO disclosed