Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123277 | 0.95 | HIF1A (0.46) | NPC1RAB9AHIF1AESR1TGFBR1 | |
| SCHEMBL5119670 | 0.90 | HIF1A (0.46) | HPGDLMNASMN1; SMN2HIF1AESR1 | |
| SCHEMBL7516589 | 0.89 | ESR1 (0.42) | ESR1TGFBR1MAPTMEN1KMT2A | |
| SCHEMBL7617098 | 0.86 | RAB9A (0.46) | NPC1RAB9AHPGDLMNACASP3 | |
| SCHEMBL5809952 | 0.85 | MAPT (0.42) | HPGDLMNASMN1; SMN2ESR1MAPT | |
| SCHEMBL7512225 | 0.84 | NPC1 (0.44) | NPC1RAB9AHPGDLMNACASP3 | |
| SCHEMBL5129136 | 0.84 | ESR1 (0.49) | NPC1RAB9AHPGDLMNACASP3 | |
| SCHEMBL5118413 | 0.84 | ESR1 (0.41) | ESR1TGFBR1MAPTMEN1KMT2A | |
| SCHEMBL5117152 | 0.83 | HIF1A (0.43) | NPC1RAB9AHIF1AMAPTMEN1 | |
| SCHEMBL5119891 | 0.81 | METAP1 (0.44) | NPC1RAB9AHPGDSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |