Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 20/20 | 0.38 |
| ▸ | AXL | P30530 | 10/20 | 0.35 |
| ▸ | FLT3 | P36888 | 10/20 | 0.35 |
| ▸ | MERTK | Q12866 | 10/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762730 | 0.93 | IDO1 (0.36) | TYRO3AXLFLT3MERTKMAP4K4 | |
| SCHEMBL1763188 | 0.89 | TYRO3 (0.37) | TYRO3AXLFLT3MERTK | |
| SCHEMBL1762975 | 0.88 | ALOX5AP (0.41) | — | |
| SCHEMBL1762649 | 0.86 | TYRO3 (0.41) | TYRO3AXLFLT3MERTK | |
| SCHEMBL1762782 | 0.82 | PDE10A (0.33) | — | |
| SCHEMBL1762703 | 0.79 | GABRP (0.32) | — | |
| SCHEMBL1762776 | 0.77 | C5AR1 (0.31) | — | |
| SCHEMBL1762598 | 0.76 | — | — | |
| SCHEMBL1762871 | 0.75 | NR4A2 (0.37) | — | |
| SCHEMBL1762996 | 0.75 | NPC1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042102-A2 | PYRROLO-PYRIDINE, PYRROLO-PYRIMIDINE AND RELATED HETEROCYCLIC COMPOUNDS | NEUROGEN CORPORATION (US) | 2006-04-20 | — | — | WO | disclosed |