Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 7/20 | 0.51 |
| ▸ | RHEB | Q15382 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8610747 | 0.84 | NPBWR1 (0.60) | NPBWR1RHEBMEN1KMT2AKDM4E | |
| SCHEMBL1838646 | 0.83 | NPBWR1 (0.51) | NPBWR1AMY1APTGESF2F10 | |
| SCHEMBL5820885 | 0.83 | RHEB (0.55) | RHEBPTGESMEN1KMT2AKDM4E | |
| SCHEMBL3183363 | 0.81 | NPBWR1 (0.63) | NPBWR1RHEBMEN1KMT2AKDM4E | |
| SCHEMBL1838648 | 0.81 | NPBWR1 (0.54) | NPBWR1AMY1AF2F10PLG | |
| SCHEMBL6124798 | 0.81 | NPBWR1 (0.54) | NPBWR1AMY1AF2F10PLG | |
| SCHEMBL6124794 | 0.81 | NPBWR1 (0.54) | NPBWR1AMY1AF2F10PLG | |
| SCHEMBL31154156 | 0.79 | NPBWR1 (0.58) | NPBWR1AMY1AF2F10PLG | |
| SCHEMBL18229611 | 0.78 | NPBWR1 (0.60) | NPBWR1AMY1AF2F10PLG | |
| SCHEMBL1170648 | 0.78 | KDM4E (0.61) | RHEBMEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124780-A2 | IH-BENZO [D] IMIDAZOLE COMPOUNDS AS INHIBITORS OF B-RAF KINASE | KALYPSYS, INC. (US) | 2006-11-23 | — | — | WO | disclosed |