Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819091 | 0.99 | DGAT1 (0.40) | DYRK2DGAT1HDAC8HDAC6ADORA1 | |
| SCHEMBL5816946 | 0.97 | HDAC8 (0.40) | DYRK2DGAT1HDAC8HDAC6ADORA1 | |
| SCHEMBL5819839 | 0.92 | MAPK14 (0.42) | DYRK2DGAT1IDH1IDH2MAPK9 | |
| SCHEMBL5818643 | 0.92 | MAPK14 (0.41) | DYRK2DGAT1IDH1IDH2MAPK9 | |
| SCHEMBL5819127 | 0.92 | BRAF (0.44) | DYRK2DGAT1IDH1IDH2MAPK9 | |
| SCHEMBL5818809 | 0.90 | MAPK9 (0.48) | DYRK2IDH1IDH2MAPK1MAPK9 | |
| SCHEMBL5813407 | 0.90 | MAPK9 (0.48) | DYRK2DGAT1IDH1IDH2MAPK1 | |
| SCHEMBL5814884 | 0.89 | SYK (0.40) | DYRK2DGAT1IDH1IDH2MAPK9 | |
| SCHEMBL5818628 | 0.89 | BRAF (0.47) | DYRK2IDH1IDH2BRAF | |
| SCHEMBL5817801 | 0.88 | SYK (0.45) | DYRK2IDH1IDH2MAPK1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |