SCHEMBL5814486

SCHEMBL5814486

COc1cc2c(cc1OC)-c1c(c3cc(Br)ccc3n1CC(=O)NCCCN(C)C)CC(=O)N2

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 11/20 0.57
CCNB2 O95067 10/20 0.49
CCNB1 P14635 10/20 0.49
GSK3B P49841 10/20 0.49
CCNB3 Q8WWL7 10/20 0.49
CDK5 Q00535 3/20 0.46
CDK5R1 Q15078 2/20 0.46
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
IDO1 P14902 1/20 0.36
PRKD3 O94806 2/20 0.36
MBTD1 Q05BQ5 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CHEK1 O14757 1/20 0.36
DAPK3 O43293 1/20 0.36
MAP4K4 O95819 1/20 0.36
PAK4 O96013 1/20 0.36
ABL1 P00519 1/20 0.36
LCK P06239 1/20 0.36
RET P07949 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5823198 0.91 CDK1 (0.57) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5806193 0.90 CDK1 (0.56) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5801919 0.88 CDK1 (0.69) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5819011 0.86 CDK1 (0.55) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5803817 0.84 CDK1 (0.64) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5802549 0.83 CDK1 (0.71) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5805683 0.81 CDK1 (0.65) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5819216 0.79 CDK1 (0.47) CDK1CCNB2CCNB1GSK3BCCNB3
SCHEMBL5816419 0.79 CDK1 (0.47) CDK1CCNB2CCNB1GSK3BCCNB3
Hydrochloric Acid SCHEMBL5813979 0.78 CDK1 (0.47) CDK1CCNB2CCNB1GSK3BCCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006089874-A1 BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONES GPC BIOTECH AG (DE) 2006-08-31 WO disclosed