Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.61 |
| ▸ | HTT | P42858 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | NPC1 | O15118 | 8/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 11/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | NQO1 | P15559 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814635 | 1.00 | KDM4E (0.61) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5813715 | 0.90 | NPC1 (0.61) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5813718 | 0.90 | NPC1 (0.61) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5814666 | 0.90 | NPC1 (0.61) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5815653 | 0.89 | NPC1 (0.74) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL13549798 | 0.89 | NPC1 (0.74) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5815648 | 0.89 | NPC1 (0.74) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5809168 | 0.84 | KMT2A (0.60) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL21436024 | 0.84 | KMT2A (0.60) | KDM4EHTTKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL29490358 | 0.84 | KMT2A (0.60) | KDM4EHTTKMT2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |