Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 20/20 | 0.74 |
| ▸ | SRC | P12931 | 14/20 | 0.74 |
| ▸ | TEK | Q02763 | 13/20 | 0.74 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815010 | 0.90 | LCK (0.92) | LCKSRCTEKKDRFYN | |
| SCHEMBL7702773 | 0.85 | SRC (1.00) | LCKSRCTEKKDRFYN | |
| SCHEMBL7702761 | 0.85 | SRC (1.00) | LCKSRCTEKKDRFYN | |
| SCHEMBL5813953 | 0.82 | SRC (0.56) | LCKSRCTEKKDRFYN | |
| Acetic Acid SCHEMBL6430304 | 0.82 | LCK (0.92) | LCKSRCTEKKDRFYN | |
| Acetic Acid SCHEMBL6430306 | 0.82 | LCK (0.92) | LCKSRCTEKKDRFYN | |
| SCHEMBL6665059 | 0.81 | LCK (0.60) | LCKSRCTEKKDRFYN | |
| SCHEMBL5819873 | 0.78 | ABL1 (0.61) | LCKSRCTEKKDRFYN | |
| SCHEMBL5819470 | 0.77 | SRC (0.56) | LCKSRCTEKKDRFYN | |
| SCHEMBL6669730 | 0.76 | SRC (0.49) | LCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |