Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.49 |
| ▸ | LCK | P06239 | 6/20 | 0.49 |
| ▸ | TEK | Q02763 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.43 |
| ▸ | EGFR | P00533 | 9/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.43 |
| ▸ | HCK | P08631 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.43 |
| ▸ | MTOR | P42345 | 8/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.43 |
| ▸ | PRKDC | P78527 | 8/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804660 | 0.88 | SRC (0.61) | SRCLCKTEKABL1EGFR | |
| SCHEMBL5823810 | 0.86 | SRC (0.49) | SRCLCKTEKABL1EGFR | |
| SCHEMBL6431132 | 0.77 | LCK (0.79) | SRCLCKTEKEGFRKDR | |
| SCHEMBL6431127 | 0.77 | LCK (0.79) | SRCLCKTEKEGFRKDR | |
| SCHEMBL5815012 | 0.76 | LCK (0.74) | SRCLCKTEKKDR | |
| SCHEMBL5823957 | 0.76 | LCK (0.56) | SRCLCKTEKABL1EGFR | |
| SCHEMBL4827342 | 0.75 | SRC (0.60) | SRCLCKTEKABL1EGFR | |
| SCHEMBL5817995 | 0.75 | LCK (0.64) | SRCLCKTEKABL1EGFR | |
| SCHEMBL6245151 | 0.75 | EGFR (0.44) | SRCLCKTEKABL1EGFR | |
| SCHEMBL6431131 | 0.75 | SRC (0.58) | SRCLCKTEKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |