Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 17/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486778 | 1.00 | SLC6A4 (0.61) | SLC6A4SLC6A2SLC6A3TACR1KCNH2 | |
| Fumaric Acid SCHEMBL4482404 | 0.90 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL4482407 | 0.90 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4495211 | 0.86 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL4486971 | 0.83 | NOS3 (0.53) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL654900 | 0.83 | NOS3 (0.53) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4483156 | 0.82 | SLC6A4 (0.71) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4489392 | 0.78 | SLC6A2 (0.57) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| Fumaric Acid SCHEMBL4493089 | 0.78 | SLC6A2 (0.71) | SLC6A4SLC6A2SLC6A3TACR1 | |
| Fumaric Acid SCHEMBL4493084 | 0.78 | SLC6A2 (0.71) | SLC6A4SLC6A2SLC6A3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |