Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.64 |
| ▸ | GSK3A | P49840 | 9/20 | 0.64 |
| ▸ | AURKA | O14965 | 7/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1204311 | 0.86 | GSK3B (0.71) | GSK3BGSK3AAURKAMARK3TNK2 | |
| SCHEMBL5805486 | 0.78 | GSK3B (1.00) | GSK3BGSK3AAURKAMARK3TNK2 | |
| SCHEMBL14940925 | 0.75 | MAPT (0.39) | GSK3BGSK3ARPS6KA3 | |
| SCHEMBL1203985 | 0.73 | GSK3A (0.53) | GSK3BGSK3ATNK2 | |
| SCHEMBL1202703 | 0.71 | GSK3B (0.58) | GSK3BGSK3AAURKAMARK3 | |
| SCHEMBL1203963 | 0.71 | GSK3B (0.57) | GSK3BGSK3AAURKAMARK3 | |
| SCHEMBL17780574 | 0.69 | RPS6KA3 (0.64) | GSK3BGSK3AAURKARPS6KA3 | |
| SCHEMBL5803329 | 0.68 | GSK3B (0.64) | GSK3BGSK3AAURKAAURKB | |
| SCHEMBL15498579 | 0.68 | GSK3B (0.59) | GSK3BGSK3AAURKAMARK3 | |
| SCHEMBL5804759 | 0.68 | GSK3B (1.00) | GSK3BGSK3AAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |