Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5936823 | 0.84 | MAPK1 (0.42) | MAPTALDH1A1HPGDCASP1HSD17B10 | |
| SCHEMBL15824039 | 0.82 | BRPF1 (0.36) | BRPF1CREBBPALDH1A1HPGDCASP1 | |
| SCHEMBL3670859 | 0.79 | GAA (0.42) | MAPTALDH1A1HPGDPOLBGAA | |
| SCHEMBL21491922 | 0.78 | RPS6KA3 (0.36) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL21261609 | 0.78 | RPS6KA3 (0.36) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL5815549 | 0.75 | GSK3B (0.64) | GSK3BGSK3ARPS6KA3 | |
| SCHEMBL16390761 | 0.74 | PLK2 (0.44) | MAPTPIN1BRD4RPS6KA3HCRTR2 | |
| SCHEMBL14952202 | 0.74 | PIN1 (0.39) | MAPTALDH1A1HPGDPOLBGAA | |
| SCHEMBL5937139 | 0.74 | MAPK1 (0.38) | MAPTALDH1A1HPGDCASP1HSD17B10 | |
| SCHEMBL5937040 | 0.72 | MAPK1 (0.36) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | disclosed |
| US-20140315911-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC | 2014-10-23 | — | — | US | disclosed |
| EP-2776444-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013071217-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2013071217-A1 | DIHYDROPTERIDINONES | OSI Pharmaceuticals, LLC (US) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315911-A1 | DIHYDROPTERIDINONES | DHPS, DHODH, HYPK | MAPT 2490/4885BRPF1 4063/4885CREBBP 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.