Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819098 | 0.89 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5814561 | 0.88 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5819170 | 0.86 | CAMK2D (0.47) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5819768 | 0.84 | CAMK2D (0.47) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5815614 | 0.84 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5812705 | 0.83 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5812866 | 0.83 | MAPK8 (0.39) | MAPK14MAPK13MAPK12MAPK9PRKD3 | |
| SCHEMBL5819507 | 0.83 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5824185 | 0.81 | MAPK13 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5816357 | 0.81 | RET (0.39) | MAPK14MAPK13MAPK12MAPK9RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |