Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795429 | 0.90 | PLG (0.51) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL582270 | 0.89 | PLG (0.52) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL582166 | 0.86 | PLG (0.49) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL3075343 | 0.84 | PLG (0.42) | PLGGABRA1GABRG2GABRB3OPRL1 | |
| SCHEMBL27869837 | 0.84 | PLG (0.42) | PLGGABRA1GABRG2GABRB3OPRL1 | |
| SCHEMBL581069 | 0.84 | PLG (0.54) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL581115 | 0.83 | PLG (0.41) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL3069351 | 0.83 | PLG (0.41) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL597997 | 0.83 | PLG (0.41) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL587162 | 0.83 | PLG (0.41) | PLGGABRA1GABRG2GABRB3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |