SCHEMBL581746

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL14433685	0.89	DYRK1A (0.44)	DYRK1APLK4AURKAAURKBTPX2
	SCHEMBL1265675	0.80	KDR (0.60)	AURKAAURKBTPX2TEKKDR
	SCHEMBL1265647	0.79	KDR (0.50)	AURKAAURKBTPX2TEKKDR
	SCHEMBL1265245	0.78	KDR (0.52)	KDM4EALDH1A1AURKAAURKBTPX2
	SCHEMBL580637	0.76	AURKA (0.70)	KDM4EALDH1A1CYP1A2CYP3A4CYP2C9
	SCHEMBL973578	0.76	TEK (0.68)	AURKAAURKBTEKKDRLCK
	SCHEMBL580385	0.75	TEK (0.60)	AURKAAURKBTPX2TEKKDR
	SCHEMBL1265668	0.75	KDR (0.54)	DYRK1ACYP1A2CYP3A4CYP2C9CYP2C19
	SCHEMBL1266047	0.75	KDR (0.54)	PLK4CYP3A4RETAURKAAURKB
	SCHEMBL1264283	0.75	AURKB (0.51)	AURKAAURKBTPX2TEKKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.