Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | ELANE | P08246 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL21082732 | 1.00 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Benzophenone SCHEMBL8089683 | 0.92 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Alcohol SCHEMBL29268730 | 0.91 | SRD5A2 (0.78) | ALDH1A1SRD5A2HPGDRAB9AELANE | |
| Benzophenone SCHEMBL11693944 | 0.90 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Alcohol SCHEMBL29206116 | 0.89 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Benzophenone SCHEMBL27461157 | 0.87 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Benzophenone SCHEMBL27621952 | 0.87 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Benzophenone SCHEMBL28189278 | 0.87 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Alcohol SCHEMBL28677724 | 0.87 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| Alcohol SCHEMBL11267582 | 0.87 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006108204-A1 | PHOTOPOLYMERISABLE MIXTURES COMPRISING PHOTOINITIATORS BASED ON BENZOPHENONE AND PHENYLGLYCINE | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2006-10-19 | — | — | WO | disclosed |