Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | FCER2 | P06734 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816953 | 0.97 | KMT2A (0.56) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5817670 | 0.93 | KMT2A (0.63) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| Acetamide SCHEMBL5824181 | 0.89 | KMT2A (0.59) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| Acetamide SCHEMBL5824177 | 0.89 | KMT2A (0.59) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5482789 | 0.87 | KMT2A (0.66) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5482792 | 0.87 | KMT2A (0.66) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5469474 | 0.85 | DHFR (0.63) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5469468 | 0.85 | DHFR (0.63) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5824119 | 0.85 | KMT2A (0.80) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5824116 | 0.85 | KMT2A (0.80) | KMT2AMEN1MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | claimed |
| EP-1732893-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | Pfizer Japan, Inc. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |
| WO-2005092858-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | PFIZER JAPAN INC. (JP) | 2005-10-06 | — | — | WO | disclosed |