Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796380 | 0.90 | MAPK11 (0.39) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5795738 | 0.89 | MAPK13 (0.46) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5799224 | 0.88 | MAPK13 (0.37) | MAPK13MAPK11CYP2C9CYP3A4KDM4E | |
| SCHEMBL5813023 | 0.88 | CYP2C9 (0.37) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5798480 | 0.86 | MAPK13 (0.40) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5795722 | 0.86 | MCHR1 (0.36) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5795724 | 0.83 | MAPK13 (0.37) | MAPK13MAPK11CYP2C9CHEK2CYP3A4 | |
| SCHEMBL5798785 | 0.80 | KDM4E (0.36) | CHEK2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL5796363 | 0.78 | SLC5A1 (0.37) | MAPK13MAPK11CYP2C9PIM1MAPK12 | |
| SCHEMBL5796356 | 0.78 | MAPK13 (0.40) | MAPK13MAPK11CYP2C9CHEK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |