SCHEMBL5817841

SCHEMBL5817841

CCOC(=O)[CH]CCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
HCAR2 Q8TDS4 1/20 0.46
GPR52 Q9Y2T5 5/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
AKR1B10 O60218 1/20 0.44
AKR1B1 P15121 1/20 0.44
ALOX5 P09917 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28057040 0.91 FFAR1 (0.47) MAPTSMN1; SMN2L3MBTL1GPR52
SCHEMBL1268421 0.83 MAPT (0.62) MAPTHCAR2GPR52
SCHEMBL1268422 0.83 MAPT (0.62) MAPTHCAR2GPR52
SCHEMBL290693 0.82 MAPT (0.51) MAPTSMN1; SMN2L3MBTL1HCAR2MEN1
SCHEMBL7518761 0.82 GPR52 (0.48) SMN1; SMN2HCAR2GPR52TDP1HDAC2
SCHEMBL27712732 0.82 GLA (0.56) MAPTSMN1; SMN2L3MBTL1GPR52KMT2A
SCHEMBL27311625 0.81 MAPT (0.59) MAPTHCAR2GPR52
SCHEMBL27310629 0.81 MAPT (0.59) MAPTHCAR2GPR52
SCHEMBL27310628 0.81 MAPT (0.59) MAPTHCAR2GPR52
SCHEMBL27311627 0.81 MAPT (0.59) MAPTHCAR2GPR52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0239062-B1 N2-(1-CARBOXY-3-OXO-3-PHENYLPROPYL)-L-LYSINE COMPOUNDS AND THEIR DERIVATIVES KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-05-29 EP claimed
EP-0187956-A2 Pharmaceutical composition for the treatment of defects of the gastrointestinal mucous membrane BOEHRINGER INGELHEIM KG (DE) 1986-07-23 EP claimed
CN-116262711-A Purification method of lisinopril hydride 浙江华海药业股份有限公司 2023-06-16 CN disclosed
CN-113698313-A Method for recovering lisinopril chiral intermediate 浙江华海药业股份有限公司 2021-11-26 CN disclosed
CN-109021064-A A kind of preparation method of enalapril maleate 扬子江药业集团有限公司 2018-12-18 CN disclosed
CN-104086623-A Novel compounds with effects of reducing blood pressure and protecting cells MUDANJIANG YOUBO PHARMACEUTICAL CO LTD 2014-10-08 CN disclosed
CN-202568933-U Novel amlodipine and benazepril capsule HEILONGJIANG FUHE HUAXING PHARMACEUTICAL GROUP CO LTD 2012-12-05 CN disclosed
WO-2006137082-A1 PROCESS FOR INDUSTRIALLY VIABLE PREPARATION OF PERINDOPRIL ERBUMINE POTLURI RAMESH BABU (IN) 2006-12-28 WO disclosed
EP-0650476-B1 PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OTSUKA PHARMA CO LTD (JP) 2002-06-26 EP disclosed
US-6136826-A AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
CN-1052224-C Peripheral Vasodilating agent containing N-acylated 4-amino piperidine derivatives as active ingredients OTSUKA PHARMA CO LTD (JP) 2000-05-10 CN disclosed
US-5760058-A Peripheral vasodilating agent containing piperidine derivative as active ingredient OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-06-02 US disclosed
US-5656642-A Peripheral vasodilating agent containing piperidine derivative as active ingredient OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-08-12 US disclosed
EP-0719280-A1 PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (SI) 1996-07-03 EP disclosed
WO-1996002564-A1 PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, D.D. (SI) 1996-02-01 WO disclosed
EP-0650476-A1 PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-05-03 EP disclosed
WO-1994022826-A1 PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-10-13 WO disclosed
EP-0213499-A2 Amino acid derivatives, process for their preparation and use BOEHRINGER INGELHEIM KG (DE) 1987-03-11 EP disclosed