Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 8/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819871 | 0.90 | AKT3 (0.41) | KCNH2BRAFRAF1CCNT1CCNA2 | |
| SCHEMBL5818352 | 0.84 | CCNT1 (0.44) | KCNH2BRAFRAF1CCNT1CCNA2 | |
| SCHEMBL5815121 | 0.83 | BRAF (0.50) | KCNH2BRAFRAF1MAPK14 | |
| SCHEMBL5819170 | 0.83 | CAMK2D (0.47) | RAF1MAPK14 | |
| SCHEMBL5819126 | 0.83 | CCNT1 (0.43) | BRAFRAF1CCNT1CCNA2CDK2 | |
| SCHEMBL5814974 | 0.82 | BRAF (0.47) | KCNH2BRAFRAF1 | |
| SCHEMBL5814640 | 0.81 | BRAF (0.47) | KCNH2BRAFRAF1CDK2MAPK14 | |
| SCHEMBL5819537 | 0.80 | MAPK14 (0.50) | BRAFRAF1MAPK14 | |
| SCHEMBL5819459 | 0.80 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL5818795 | 0.79 | HRH4 (0.43) | BRAFRAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |