Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CCNH | P51946 | 3/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.41 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5818259 | 0.88 | MAPK6 (0.57) | MAPK6GSK3AGSK3BCCNA2CDK2 | |
| SCHEMBL5820034 | 0.87 | MAPK6 (0.53) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL5816705 | 0.87 | MAPK6 (0.51) | MAPK6GSK3AGSK3BCCNA2CDK2 | |
| SCHEMBL5820031 | 0.85 | MAPK6 (0.47) | MAPK6GSK3AGSK3B | |
| SCHEMBL5820185 | 0.84 | MAPK6 (0.54) | MAPK6GSK3AGSK3BCCNA2CDK2 | |
| SCHEMBL5816043 | 0.84 | MAPK6 (0.54) | MAPK6GSK3AGSK3BCCNA2CDK2 | |
| SCHEMBL5823050 | 0.82 | MAPK6 (0.51) | MAPK6GSK3AGSK3B | |
| SCHEMBL5820170 | 0.76 | GSK3A (0.75) | MAPK6GSK3AGSK3BCDK2AURKA | |
| SCHEMBL17435241 | 0.75 | MAPK6 (0.64) | MAPK6GSK3AGSK3B | |
| SCHEMBL16012827 | 0.75 | MAPK6 (0.64) | MAPK6GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |