Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820034 | 0.95 | MAPK6 (0.53) | MAPK6GSK3AGSK3BMAPK3JAK3 | |
| SCHEMBL16012387 | 0.88 | MAPK6 (0.67) | MAPK6GSK3AGSK3BMAPK3 | |
| SCHEMBL5820185 | 0.85 | MAPK6 (0.54) | MAPK6GSK3AGSK3BBTK | |
| SCHEMBL5816043 | 0.84 | MAPK6 (0.54) | MAPK6GSK3AGSK3BMAPK3 | |
| SCHEMBL5818259 | 0.84 | MAPK6 (0.57) | MAPK6GSK3AGSK3B | |
| SCHEMBL5814193 | 0.83 | MAPK6 (0.51) | MAPK6GSK3AGSK3BBTK | |
| SCHEMBL5818405 | 0.82 | MAPK6 (0.49) | MAPK6GSK3AGSK3B | |
| SCHEMBL5818509 | 0.81 | MAPK6 (0.63) | MAPK6GSK3AGSK3BMAPK3 | |
| SCHEMBL5816705 | 0.81 | MAPK6 (0.51) | MAPK6GSK3AGSK3B | |
| SCHEMBL5820031 | 0.81 | MAPK6 (0.47) | MAPK6GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |