Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 17/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805181 | 0.92 | PTGIR (0.72) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5803206 | 0.81 | PTGIR (0.76) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5802923 | 0.80 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL5806185 | 0.79 | PTGIR (0.97) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5803970 | 0.79 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL11163847 | 0.78 | ADRA2A (0.88) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5803227 | 0.78 | ADRA2A (0.88) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5807405 | 0.77 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL11166308 | 0.77 | ADRA2A (0.85) | PTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5804024 | 0.76 | PTGIR (1.00) | PTGIRADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656350-A2 | THIOPHENYLAMINOIMIDAZOLINES AS PROSTAGLANDIN I2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005005394-A2 | THIOPHENYLAMINOIMIDAZOLINES AS PROSTAGLANDIN I2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-01-20 | — | — | WO | disclosed |