Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814867 | 0.96 | KCNH2 (0.51) | MAPK8MAPK9KCNH2PRKD3MAP4K4 | |
| SCHEMBL5814974 | 0.90 | BRAF (0.47) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5814640 | 0.89 | BRAF (0.47) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5813645 | 0.89 | EIF2AK2 (0.44) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5817804 | 0.88 | EIF2AK2 (0.43) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5818943 | 0.88 | KCNH2 (0.46) | EGFRKCNH2 | |
| SCHEMBL5818443 | 0.87 | KCNH2 (0.45) | EGFRKCNH2 | |
| SCHEMBL5815121 | 0.86 | BRAF (0.50) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5816357 | 0.86 | RET (0.39) | MAPK8MAPK9EGFRRAF1ERBB2 | |
| SCHEMBL5819462 | 0.85 | CDK1 (0.40) | MAPK8MAPK9EGFRRAF1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |