Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813645 | 0.99 | EIF2AK2 (0.44) | EIF2AK2MAPK8MAPK9KDREGFR | |
| SCHEMBL5812889 | 0.96 | IKBKB (0.42) | EIF2AK2MKNK1IKBKBBRD4KCNH2 | |
| SCHEMBL5819019 | 0.89 | HTR6 (0.43) | EIF2AK2MAPK9IKBKBALDH1A1MAPT | |
| SCHEMBL5819371 | 0.88 | IKBKB (0.43) | EIF2AK2MAPK9IKBKBALDH1A1HPGD | |
| SCHEMBL5818906 | 0.88 | MAPK8 (0.51) | MAPK8MAPK9KDREGFRRAF1 | |
| SCHEMBL5819021 | 0.86 | EIF2AK2 (0.44) | EIF2AK2MAPK8MAPK9KDREGFR | |
| SCHEMBL5819375 | 0.85 | EIF2AK2 (0.44) | EIF2AK2MAPK8MAPK9KDRMKNK1 | |
| SCHEMBL5818981 | 0.85 | IKBKB (0.45) | MAPK8MAPK9IKBKBALDH1A1HPGD | |
| SCHEMBL5814867 | 0.84 | KCNH2 (0.51) | MAPK8MAPK9KCNH2MAPK1GSK3A | |
| SCHEMBL5817822 | 0.84 | MAPK14 (0.46) | MAPK8MAPK9KDREGFRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |