Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.47 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819159 | 0.99 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14MAPK8 | |
| SCHEMBL5819153 | 0.95 | MAPK14 (0.50) | MAPK13MAPK12MAPK11MAPK14MAPK8 | |
| SCHEMBL5816324 | 0.87 | BRAF (0.49) | MAP4K4MAPK1GSK3BHIPK2ALK | |
| SCHEMBL5811808 | 0.86 | BRAF (0.48) | MAPK8MAPK9MAP4K4MAPK1GSK3B | |
| SCHEMBL5817943 | 0.86 | EIF2AK2 (0.50) | MAPK8MAPK9CDK4MAPK10CDK2 | |
| SCHEMBL5818203 | 0.85 | EIF2AK2 (0.49) | MAPK8MAPK9MAP4K4GSK3BHIPK2 | |
| SCHEMBL5813505 | 0.82 | BRAF (0.52) | MAPK13MAPK12MAPK11MAPK14MAPK8 | |
| SCHEMBL1034820 | 0.81 | CDK4 (0.57) | MAPK13MAPK12MAPK11MAPK14MAPK8 | |
| SCHEMBL5819164 | 0.81 | CDK1 (0.46) | MAPK13MAPK12MAPK14MAPK8MAPK9 | |
| SCHEMBL5818196 | 0.81 | EIF2AK2 (0.45) | MAPK8MAPK9GSK3BCLK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |