Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5817943 | 0.96 | EIF2AK2 (0.50) | EIF2AK2IKBKBCDK4MKNK1PIK3CA | |
| SCHEMBL5818203 | 0.95 | EIF2AK2 (0.49) | EIF2AK2IKBKBGSK3BCDK4MAPK8 | |
| SCHEMBL5819153 | 0.85 | MAPK14 (0.50) | IKBKBGSK3BCDK4CLK2CLK4 | |
| SCHEMBL5819338 | 0.81 | MAPK13 (0.48) | GSK3BCDK4CLK2CLK4MAPK8 | |
| SCHEMBL5819159 | 0.80 | MAPK13 (0.48) | GSK3BCDK4CLK2MAPK8MAPK9 | |
| SCHEMBL5813443 | 0.79 | MAPK14 (0.45) | IKBKBGSK3BCDK4MAPK8MAPK9 | |
| SCHEMBL5817158 | 0.78 | KCNH2 (0.58) | ACHE | |
| SCHEMBL1034547 | 0.77 | EIF2AK2 (0.58) | EIF2AK2IKBKBGSK3BCDK4PIK3CA | |
| SCHEMBL5813440 | 0.77 | KMT2A (0.64) | IKBKBACHEMEN1KMT2A | |
| SCHEMBL5815611 | 0.77 | KCNH2 (0.54) | IKBKBMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |