Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582329 | 0.88 | POLB (0.42) | POLBENPP2FFAR4ALDH1A1LMNA | |
| SCHEMBL582008 | 0.88 | POLB (0.42) | POLBENPP2FFAR4ALDH1A1LMNA | |
| SCHEMBL582009 | 0.88 | POLB (0.42) | POLBENPP2FFAR4ALDH1A1LMNA | |
| SCHEMBL581486 | 0.85 | FFAR4 (0.40) | POLBENPP2FFAR4ALDH1A1LMNA | |
| SCHEMBL581788 | 0.85 | HSD17B10 (0.40) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL582351 | 0.80 | POLB (0.48) | POLBENPP2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL599010 | 0.77 | CYP11B1 (0.39) | POLBALDH1A1LMNASMN1; SMN2EPHX2 | |
| SCHEMBL581169 | 0.77 | CYP11B1 (0.39) | POLBALDH1A1LMNASMN1; SMN2EPHX2 | |
| SCHEMBL581644 | 0.77 | CYP11B1 (0.39) | POLBALDH1A1LMNASMN1; SMN2EPHX2 | |
| SCHEMBL582160 | 0.76 | KMT2A (0.41) | POLBALDH1A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |