Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075410 | 0.86 | KMT2A (0.43) | KMT2AMEN1MAPK1HTTCHRM1 | |
| SCHEMBL3075467 | 0.86 | KMT2A (0.43) | KMT2AMEN1MAPK1HTTCHRM1 | |
| SCHEMBL580925 | 0.86 | KMT2A (0.43) | KMT2AMEN1MAPK1HTTCHRM1 | |
| SCHEMBL586931 | 0.84 | KDM4E (0.39) | KMT2AMEN1MAPK1ALDH1A1TDP1 | |
| SCHEMBL582364 | 0.81 | HTR2A (0.41) | KMT2AMEN1MAPK1CHRM1ALDH1A1 | |
| SCHEMBL581788 | 0.79 | HSD17B10 (0.40) | KMT2AMEN1HTTCHRM1ALDH1A1 | |
| SCHEMBL582882 | 0.77 | ALDH1A1 (0.44) | KMT2AMEN1HTTALDH1A1TDP1 | |
| SCHEMBL581952 | 0.76 | POLB (0.43) | ALDH1A1ACHEPOLB | |
| SCHEMBL581313 | 0.75 | GAA (0.40) | KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3072815 | 0.75 | GAA (0.40) | KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |