Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6363601 | 1.00 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL19414714 | 0.85 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL6922250 | 0.83 | CHRM2 (0.50) | CHRM2CHRM1CHRM3PREPCYP3A4 | |
| SCHEMBL29514321 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL15348379 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL15281913 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL14486578 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16549901 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16592244 | 0.82 | CHRM2 (0.47) | NR1H2CHRM2CHRM1CHRM3PREP | |
| SCHEMBL25183803 | 0.82 | CHRM2 (0.46) | NR1H2CHRM2CHRM1CHRM3PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615885-A1 | B -FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | Warner-Lambert Company LLC (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092132-A1 | [B]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |