Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | CDK4 | P11802 | 6/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819630 | 0.85 | CDK2 (0.49) | CDK2CDK4CCNE1HDAC1CDK19 | |
| SCHEMBL412401 | 0.84 | CDK2 (0.56) | CDK2CDK4CCNE1HDAC1CDK19 | |
| SCHEMBL415283 | 0.83 | CDK2 (0.49) | CDK2CDK4CCNE1HDAC1 | |
| SCHEMBL414098 | 0.82 | CDK2 (0.48) | CDK2CDK4CCNE1HDAC1 | |
| SCHEMBL411464 | 0.81 | CDK2 (0.75) | CDK2CDK4CCNE1HDAC1KDM4E | |
| SCHEMBL5138420 | 0.81 | CDK2 (0.53) | CDK2CDK4CCNE1GAAMAPT | |
| SCHEMBL409738 | 0.80 | HDAC1 (0.56) | CDK2CDK4CCNE1HDAC1 | |
| SCHEMBL413669 | 0.79 | MAPK8 (0.54) | CDK2CDK4CCNE1GAAMAPT | |
| SCHEMBL412361 | 0.79 | CDK2 (0.71) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL413670 | 0.79 | CDK19 (0.49) | CDK2CDK4CCNE1HDAC1CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546112-A4 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1546112-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004021989-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-03-18 | — | — | WO | disclosed |