Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 7/20 | 0.55 |
| ▸ | GSK3A | P49840 | 3/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361381 | 0.91 | PIM1 (0.60) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL10733510 | 0.90 | GSK3A (0.59) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL7361513 | 0.90 | MAPK13 (0.54) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL10731559 | 0.89 | MAP2K1 (0.53) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL5823296 | 0.88 | BRAF (0.57) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL7363602 | 0.88 | MAPK13 (0.57) | PIM1MAPK13BRAFGSK3AEPHA2 | |
| SCHEMBL7362738 | 0.86 | CLK4 (0.73) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL5816204 | 0.85 | PIM1 (0.59) | PIM1MAPK13BRAFGSK3AEPHA2 | |
| SCHEMBL5822141 | 0.85 | CDKN1A (0.75) | PIM1MAPK13MAP2K1CLK4DYRK1B | |
| SCHEMBL5819755 | 0.85 | CDKN1A (0.74) | PIM1MAPK13MAP2K1CLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006033795-A2 | SUBSTITUTED PYRAZOLO [1, 5-A] PYRIMIDINES FOR INHIBITING ABNORMAL CELL GROWTH | WYETH (US) | 2006-03-30 | — | — | WO | disclosed |
| US-4654347-A | USEFUL AS ANXIOLYTIC AND ANTIEPILEPTIC AGENTS, SEDATIVE-HYPNOTIC AGENTS AND SKELETAL MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |