Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | BRAF | P15056 | 10/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819944 | 0.90 | PIM1 (0.57) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL7363602 | 0.88 | MAPK13 (0.57) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL7361381 | 0.87 | PIM1 (0.60) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL10733510 | 0.87 | GSK3A (0.59) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL7360433 | 0.85 | CDKN1A (0.51) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL10731559 | 0.85 | MAP2K1 (0.53) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL5823702 | 0.85 | CDKN1A (0.71) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL5823296 | 0.84 | BRAF (0.57) | MAPK13LIMK1MARK2PIM1BRAF | |
| SCHEMBL7362738 | 0.82 | CLK4 (0.73) | MAPK13LIMK1MARK2PIM1MAP2K1 | |
| SCHEMBL5816204 | 0.82 | PIM1 (0.59) | MAPK13LIMK1MARK2PIM1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | claimed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |