Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353042 | 0.87 | HPGD (0.51) | HPGDJAK2CRHR1RAB9ANPC1 | |
| SCHEMBL5778940 | 0.87 | HPGD (0.51) | HPGDJAK2NTRK1CRHR1RAB9A | |
| SCHEMBL5778937 | 0.87 | HPGD (0.51) | HPGDJAK2NTRK1CRHR1RAB9A | |
| SCHEMBL8349012 | 0.86 | HPGD (0.46) | HPGDCRHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6063963 | 0.86 | HPGD (0.46) | HPGDCRHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8352231 | 0.86 | HPGD (0.50) | HPGDJAK2CRHR1RAB9ANPC1 | |
| SCHEMBL5841319 | 0.86 | SMYD3 (0.52) | HPGDCRHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5841315 | 0.86 | SMYD3 (0.52) | HPGDCRHR1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3174715 | 0.85 | NPC1 (0.58) | HPGDRAB9ANPC1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL6063550 | 0.85 | SMYD3 (0.51) | HPGDCRHR1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651609-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005009966-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |