Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.68 |
| ▸ | IGF1R | P08069 | 14/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 14/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 14/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | TEK | Q02763 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801987 | 0.89 | EGFR (0.84) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6430378 | 0.89 | EGFR (0.84) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL4826480 | 0.89 | EGFR (0.84) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6273557 | 0.88 | EGFR (0.61) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL7050377 | 0.86 | EGFR (0.85) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL7050383 | 0.86 | EGFR (0.85) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6867289 | 0.79 | EGFR (0.75) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6867295 | 0.79 | EGFR (0.75) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6670094 | 0.77 | LCK (0.55) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL6430512 | 0.77 | EGFR (1.00) | EGFRERBB2IGF1RERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |