Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 8/20 | 0.74 |
| ▸ | GSK3B | P49841 | 8/20 | 0.74 |
| ▸ | AURKA | O14965 | 6/20 | 0.60 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806576 | 0.85 | GSK3A (0.79) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL5820487 | 0.85 | GSK3A (1.00) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL5820761 | 0.85 | GSK3A (0.76) | GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL5823133 | 0.84 | GSK3A (0.77) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL5806572 | 0.83 | MAPK6 (0.77) | GSK3AGSK3BAURKAMAPK6MAPK8 | |
| SCHEMBL5820371 | 0.81 | GSK3A (0.69) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL5815087 | 0.79 | GSK3A (0.70) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL5816108 | 0.79 | GSK3A (0.68) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL18830621 | 0.77 | GSK3A (0.67) | GSK3AGSK3BAURKAMAPK6CDK2 | |
| SCHEMBL18830445 | 0.77 | GSK3A (0.64) | GSK3AGSK3BAURKAMAPK6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |