Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.45 |
| ▸ | SRC | P12931 | 9/20 | 0.45 |
| ▸ | TEK | Q02763 | 9/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 9/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.41 |
| ▸ | IGF1R | P08069 | 9/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.37 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273230 | 0.85 | LCK (0.45) | LCKSRCTEKKDRBTK | |
| SCHEMBL6667380 | 0.83 | BTK (0.66) | LCKSRCTEKKDRBTK | |
| SCHEMBL6688752 | 0.83 | BTK (0.42) | LCKSRCTEKKDRBTK | |
| SCHEMBL6273323 | 0.83 | EGFR (0.45) | LCKSRCTEKKDRBTK | |
| SCHEMBL5822199 | 0.83 | LCK (0.49) | LCKSRCTEKKDRBTK | |
| SCHEMBL6688969 | 0.82 | SRC (0.67) | LCKSRCTEKKDRBTK | |
| SCHEMBL5823745 | 0.82 | SRC (0.49) | LCKSRCTEKKDRBTK | |
| SCHEMBL6246605 | 0.81 | IGF1R (0.51) | LCKSRCTEKKDRBTK | |
| SCHEMBL6431294 | 0.78 | LCK (0.72) | LCKSRCTEKKDRBTK | |
| SCHEMBL6639201 | 0.78 | LCK (0.44) | LCKSRCTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |