Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.42 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 8/20 | 0.41 |
| ▸ | SRC | P12931 | 7/20 | 0.41 |
| ▸ | TEK | Q02763 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.41 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.41 |
| ▸ | CSK | P41240 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823682 | 0.87 | BTK (0.59) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL5819209 | 0.85 | SRC (0.49) | LCKSRCTEKKDREGFR | |
| SCHEMBL5820135 | 0.83 | LCK (0.45) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL6273230 | 0.83 | LCK (0.45) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL6667380 | 0.81 | BTK (0.66) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL6273323 | 0.81 | EGFR (0.45) | BTKLCKSRCTEKKDR | |
| SCHEMBL5822199 | 0.80 | LCK (0.49) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL5821051 | 0.80 | SRC (0.52) | BTKNUDT14NUDT5LCKSRC | |
| SCHEMBL6688969 | 0.80 | SRC (0.67) | BTKLCKSRCTEKKDR | |
| SCHEMBL5823745 | 0.79 | SRC (0.49) | BTKLCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |