Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 6/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16392665 | 0.83 | EPHX1 (0.47) | KDM4EMAPK1HIF1APAOXACHE | |
| SCHEMBL16392579 | 0.82 | EPHX1 (0.52) | KDM4EMAPK1HIF1APAOXNAAA | |
| SCHEMBL38658712 | 0.80 | PAOX (0.62) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL10309189 | 0.80 | EPHX1 (0.55) | KDM4EMAPK1HIF1APAOXNAAA | |
| SCHEMBL10017869 | 0.79 | PAOX (0.60) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL48733 | 0.77 | — | — | |
| SCHEMBL349682 | 0.77 | KDM4E (0.34) | KDM4EMAPK1HIF1A | |
| SCHEMBL4099586 | 0.77 | CA1 (0.46) | PTGS1KCNH2TDP1CA1CA2 | |
| SCHEMBL4105469 | 0.74 | CA1 (0.37) | CA1CA2CA12CA9 | |
| SCHEMBL30544644 | 0.73 | OTC (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006088694-A1 | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS | WYETH (US) | 2006-08-24 | — | — | WO | claimed |
| WO-2006088694-A1 | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |