Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.69 |
| ▸ | GSK3B | P49841 | 2/20 | 0.69 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816897 | 0.87 | GSK3A (0.73) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5818485 | 0.85 | GSK3A (0.73) | GSK3AGSK3BMAPK6ADORA2AMAPK8 | |
| SCHEMBL5820487 | 0.82 | GSK3A (1.00) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL16012652 | 0.82 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5818337 | 0.82 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL16012808 | 0.82 | MAPK6 (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5819986 | 0.79 | GSK3A (0.81) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL5820264 | 0.78 | GSK3A (0.80) | GSK3AGSK3BMAPK6MAPK8MAPK9 | |
| SCHEMBL15206057 | 0.77 | ADORA2A (0.58) | GSK3AGSK3BADORA2AMAPK8MAPK9 | |
| SCHEMBL15206620 | 0.77 | ADORA2A (0.58) | GSK3AGSK3BADORA2AMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |