Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | COMT | P21964 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15424138 | 0.89 | MAPT (0.75) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679611 | 0.85 | MEN1 (0.74) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424140 | 0.84 | MEN1 (0.73) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14642442 | 0.84 | MEN1 (0.79) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679581 | 0.84 | MEN1 (0.69) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14642443 | 0.84 | MEN1 (0.72) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14642412 | 0.84 | MEN1 (1.00) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15558259 | 0.83 | MEN1 (0.71) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15557427 | 0.82 | MEN1 (0.75) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424152 | 0.81 | MAPT (0.65) | MAPTMEN1HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124780-A2 | IH-BENZO [D] IMIDAZOLE COMPOUNDS AS INHIBITORS OF B-RAF KINASE | KALYPSYS, INC. (US) | 2006-11-23 | — | — | WO | disclosed |