Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578564 | 0.92 | DRD2 (0.47) | DRD2NOTUMATMSLC18A3SIGMAR1 | |
| SCHEMBL5578732 | 0.91 | DRD2 (0.48) | DRD2NOTUMATMSLC18A3SIGMAR1 | |
| SCHEMBL5579121 | 0.88 | DRD2 (0.45) | DRD2NOTUMATMSLC18A3SIGMAR1 | |
| SCHEMBL5579075 | 0.88 | DRD2 (0.45) | DRD2NOTUMATMSLC18A3SIGMAR1 | |
| SCHEMBL5578852 | 0.88 | DRD2 (0.48) | DRD2NOTUMHTR1ADRD4HTR2A | |
| SCHEMBL4893188 | 0.87 | NOTUM (0.43) | DRD2NOTUMATMPTGDR2P2RX7 | |
| SCHEMBL5578890 | 0.86 | DRD2 (0.46) | DRD2NOTUMDRD4DRD3 | |
| SCHEMBL5578519 | 0.84 | KDM4E (0.50) | DRD2NOTUMSIGMAR1PTGDR2 | |
| SCHEMBL5578496 | 0.83 | NOTUM (0.46) | DRD2NOTUMATMPTGDR2P2RX7 | |
| SCHEMBL5579087 | 0.83 | NOTUM (0.43) | DRD2NOTUMSIGMAR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |