Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100765 | 0.76 | HPGDS (0.46) | HPGDSLTA4HADRA2AADRA1AADRA1D | |
| SCHEMBL9455041 | 0.68 | HPGDS (0.35) | HPGDSLTA4H | |
| SCHEMBL16799432 | 0.68 | NOTUM (0.42) | — | |
| SCHEMBL569960 | 0.65 | NPC1 (0.48) | — | |
| SCHEMBL9454206 | 0.65 | HPGDS (0.37) | HPGDSLTA4H | |
| SCHEMBL5820538 | 0.65 | NOTUM (0.43) | HPGDS | |
| SCHEMBL967548 | 0.64 | PDPK1 (0.38) | — | |
| SCHEMBL4032194 | 0.64 | KDM4E (0.48) | — | |
| SCHEMBL5200683 | 0.64 | HPGDS (0.35) | HPGDSLTA4H | |
| SCHEMBL17701202 | 0.63 | HPGDS (0.35) | HPGDSLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658069-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005013981-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | WO | disclosed |